Patricia began her research into HLA associated adverse drug reactions in 2008 during her Bachelor of Science Honours year at The University of Melbourne (Dept. Microbiology and Immunology) in the laboratory of Prof. Jim McCluskey. Continuing in her doctoral studies, Patricia focussed on investigating the mechanisms of Abacavir Hypersensitivity Syndrome (AHS), a potentially fatal hypersensitivity reaction that occurs exclusively in individuals possessing the HLA variant HLA-B*57:01. This highly collaborative research, involving researchers from The University of Melbourne, Monash University and QIMR, gave the first explanation of how a small molecule could interact with a single HLA to stimulate an immune response. This seminal research led to a Nature publication in 2012 and a Commendation for the Victorian Premier’s Award in Health and Medical Research in 2013. Patricia received a NHMRC Peter Doherty Early Career Research Fellowship (commenced 2014) to continue her research into HLA associated adverse drug reactions in the laboratory of Prof. Tony Purcell at Monash University. Here she forms part of a team investigating the interactions of small molecules with variants of the HLA and mechanisms of drug induced T cell activation.
Abstracts this author is presenting: