Professor Christopher Overall is a Tier 1 Canada Research Chair in Protease Proteomics and an Honorary Professor Albert-Ludwigs Universität Freiburg, Germany with an h-index of 88. He was inducted as a fellow into the Royal Society of Canada in 2018. He is best known for his development of proteomic methodology for the discovery of protease substrates in vivo, thereby establishing the field of degradomics. He has used these techniques to reveal new biological roles for proteases in immunity and disease as well as new treatments to correct protease deficiency in an immunodeficiency disease. By generating clinically relevant insights into how proteases dampen disease-fighting defence systems involved in inflammation and immunodeficiency, degradomics has revealed an unexplored layer of complexity in the hierarchy of cell and immune regulation, revolutionizing our understanding of protease function and drug targeting.
Dr. Overall completed his undergraduate and Master’s degrees at the University of Adelaide, South Australia; his Ph.D. in Biochemistry at the University of Toronto, Canada; and was an MRC Centennial Fellow in his postdoctoral work with Dr. Michael Smith, Nobel Laureate, UBC. He was a Senior Scientist at British Biotech, Oxford, and at the Protease Platform, Centre for Proteomic Drug Discovery, Novartis, Basel. His advances in proteomics have been recognized by the Canadian National Proteomics Network Tony Pawson Award (2014); the Proteomass Scientific Society Award (2017); and the 2018 international HUPO Discovery Award in Proteomics Sciences. He is an Associate Editor of the Journal of Proteome Research and Chair of the C-HPP.
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