Dr. Overall is a Professor and Tier 1 Canada Research Chair in Protease Proteomics and Systems Biology at the Life Sciences Institute, the University of British Columbia (UBC), and Canadian Institutes of Health Research (CIHR) Foundation Grant holder. He is the pioneer of degradomics, a term he coined, developing world-leading innovative quantitative proteomic techniques and polymers-for-proteomics to enrich and identify proteolysis products in vivo, he has revolutionized the identification of protein natural N and C termini, proteolytic cleaved neo-N- and neo-C-termini, proteolytic proteoforms, and understanding of the roles of proteases in human physiological and pathological processes, and hence as drug targets. This has resulted in 26 Science, Nature Review, and Nature/Cell/Science-sister journal papers. His 256 papers have been cited over 25,000 times (2 > 1000; 9 > 500 citations) giving an h index of 83 (Google Scholar), and has been recognized by the Human Proteome Organization (HUPO) by the Awarding of the 2017 Discovery Award in Proteomic Sciences.
He completed his Ph.D. in Biochemistry at the University of Toronto; and was a MRC Centennial Fellow in his post-doctoral work with Dr. Michael Smith, Nobel Laureate, Biotechnology Laboratory, UBC. He started his lab at UBC in 1993, where he remains happily entrenched. On Sabbatical in 1997-1998 he was a Senior Scientist at British Biotech Pharmaceuticals, Oxford, UK, and in 2004 and 2008 a Senior Scientist at the Expert Protease Platform, Novartis Pharmaceuticals, Basel, Switzerland. At the Freiburg Institute for Advanced Studies, Albert-Ludwigs Universität Freiburg, Germany he was an External Senior Fellow, and is now an Honorary Professor there.
He is a leader in protease proteomics and degradomics, which was recognized by the 2002 CIHR Scientist of the Year, the UBC Killam Senior Researcher Award 2005, and by lifetime achievement awards e.g. the International Proteolysis Society Lifetime Achievement Award in 2011; by the Matrix Biology Society of Australia and New Zealand 2012 Barry Preston Award; and by other awards such as by the 2013 IADR Distinguished Scientist Award; and in 2014 by the Tony Pawson Canadian National Proteomics Network Award for Outstanding Contribution and Leadership to the Canadian Proteomics Community; 2017 Proteomass Scientific Society Award, and the 2017 HUPO Discovery Award in Proteomic Sciences, Human Proteome Organization.
Dr. Overall has disseminated his lab’s findings by 219 invited and plenary talks at conferences and 205 invited seminars at Universities and companies evidencing the scope and quality of his innovative research. As of March, 2017 he has mentored 56 trainees (37 PDF/13 PhD/5 MSc) with great success: 7 are Full or Associate Professors including 2 Department Chairs, 8 are Assistant Professors, 10 are industry scientists, 7 are Research Associates, and are 5 health/science professionals.
Abstracts this author is presenting: